ChloroquineV1, France, Analysis, bibRecord, 000307

Experimental pharmacological study of the antimalarial activity of a compound of synthesis: the methylthioninium chloride

Identifieur interne : 000307 ( France/Analysis ); précédent : 000306; suivant : 000308

Experimental pharmacological study of the antimalarial activity of a compound of synthesis: the methylthioninium chloride

Auteurs : Giovanny Garavito [France]

Source :

RBID : Hal:tel-00639025

Descripteurs français

mix :
- Antipaludiques, Bleu de méthylène, Chimiosensibilité, Glutathion, Hème., Interactions de drogues, Paludisme, Pharmacologie, Plasmodium, Stade sensible.
Wicri :
- topic : Pharmacologie.

English descriptors

mix :
- Chemosensitivity, Malaria, antimalarials, drug interactions, glutathione, haem., methylene blue, pharmacology, sensible stage.

Abstract

We studied the antimalarial activity of methylene blue (BM), which was the first synthetic molecule used in the treatment of malaria. We showed that BM is active on Plasmodium falciparum strains from different geographical origins and chloroquino-sensitivities (IC50<10nM). It is also active on the blood cycle of rodent malaria (ED50<15mg/Kg), but not on the hepatic phase. The most sensitive erythrocytic stages are young stages. Associations with traditional treatments are: antagonist with amodiaquine; antagonism-additive with atovaquone, doxycycline, pyrimethamine; additive-pas d'interaction with artemether, chloroquine, mefloquine, primaquine and synergistic with quinine. We showed by spectrometry UV, TLC and mass spectrometry, that there is no association between BM and hem. We also developed a new technique to measure the transformation of hem by the glutathione and to measure the activity of drugs on this transformation.

Url:

https://tel.archives-ouvertes.fr/tel-00639025

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000093
to stream Hal, to step Curation: 000093
to stream Hal, to step Checkpoint: 000220
to stream Main, to step Merge: 001A56
to stream Main, to step Curation: 001A46
to stream Main, to step Exploration: 001A46
to stream France, to step Extraction: 000307

Links to Exploration step

Hal:tel-00639025

Le document en format XML

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<title xml:lang="fr">Etude pharmacologique expérimentale de l'activité antipaludique d'un composé de synthèse: le chlorure de methylthioninium</title>
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<front><div type="abstract" xml:lang="en">              <p>We studied the antimalarial activity of methylene blue (BM), which was the first synthetic molecule used in the treatment of malaria. We showed that BM is active on Plasmodium falciparum strains from different geographical origins and chloroquino-sensitivities (IC50<10nM). It is also active on the blood cycle of rodent malaria (ED50<15mg/Kg), but not on the hepatic phase. The most sensitive erythrocytic stages are young stages. Associations with traditional treatments are: antagonist with amodiaquine; antagonism-additive with atovaquone, doxycycline, pyrimethamine; additive-pas d'interaction with artemether, chloroquine, mefloquine, primaquine and synergistic with quinine. We showed by spectrometry UV, TLC and mass spectrometry, that there is no association between BM and hem. We also developed a new technique to measure the transformation of hem by the glutathione and to measure the activity of drugs on this transformation.</p>
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{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:tel-00639025
   |texte=   Experimental pharmacological study of the antimalarial activity of a compound of synthesis: the methylthioninium chloride
}}

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Experimental pharmacological study of the antimalarial activity of a compound of synthesis: the methylthioninium chloride

Experimental pharmacological study of the antimalarial activity of a compound of synthesis: the methylthioninium chloride

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri